Letrozole is a medication used for the treatment of breast cancer in postmenopausal women. It belongs to a class of drugs known as aromatase inhibitors, which work by decreasing the production of estrogen in the body. Estrogen can stimulate the growth of certain types of breast cancer cells, so reducing its levels can help slow or stop the progression of the disease.

Letrozole is commonly prescribed to women who have hormone receptor-positive breast cancer, meaning that their cancer cells rely on estrogen to grow. By inhibiting the enzyme aromatase, which is responsible for producing estrogen, letrozole effectively lowers estrogen levels in the body and starves the cancer cells of the hormone they need to thrive.

Aside from treating breast cancer, letrozole is also sometimes used off-label to induce ovulation in women with infertility issues. This is because lowering estrogen levels can trigger the release of hormones that stimulate ovulation, increasing the chances of conception for some women.

Like any medication, letrozole can have side effects, including hot flashes, fatigue, joint pain, and an increased risk of osteoporosis. It is important for patients to discuss the potential risks and benefits of letrozole with their healthcare provider before starting treatment.

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Letrozole Study Finds Positive Effects on Fertility and Hormone Levels


In conclusion, the effects of letrozole can vary depending on individual factors and medical conditions. It is important to consult with a healthcare provider before starting this medication to ensure safe and effective use.